Symptoms of Depression
Depression: Major Depression & Unipolar Varieties
Resources
Basic Information
Introduction and Types of DepressionRelated Disorders / ConditionsHistorical and Current UnderstandingsBiology, Psychology and SociologyTreatment - Medication and PsychotherapyAlternative Medicine and Self-Help ResourcesSpecial IssuesReferences
More InformationTestsLatest News
Phone Care Can Help Combat Post-Heart Surgery DepressionClinical Trials Update: Nov. 16, 2009Depression Linked to Immune Response in PregnancyClinical Trials Update: Nov. 12, 2009Health Tip: Symptoms of Postpartum DepressionBrain Stimulation May Ease Treatment-Resistant DepressionClinical Trials Update: Nov. 9, 2009Adjunctive Psychotherapy for Depression StudiedDepression May Blur Memory of Aches and PainsCognitive Behavioral Therapy Helps Overcome Winter BluesPsychotherapy Beats Light Treatment for SADPhone Counseling for Depression Rings With PromiseDepression Often Goes Untreated in Working MomsConstant Light Linked to Symptoms of DepressionOmega-3 Augmentation of Antidepressant EvaluatedSuicidal Thoughts May Vary by AntidepressantImpact of Maternal Depression and Abuse on Children StudiedRecession Adds to Ranks of Americans With DepressionDepression, Anxiety May Raise Odds of ObesityTelephone Care and Therapy Help to Treat DepressionMother's Use of Antidepressant May Carry Risks for NewbornTroubled Minds Can Mean Wider WaistlinesTeens With ADHD, Depression Risk Internet AddictionAntidepressants May Be Linked to Birth ProblemsMediterranean Diet May Help Prevent DepressionAntidepressants Linked to Heart Defects in NewbornsPredicting Postpartum Depression May Be PossibleDrinking, Weight, Depression Linked in Young Women: StudyHealth Care Assistants May Be Useful in Depression CareDepression May Hasten Cancer DeathStudies Explore Genetic Factors Underlying DepressionSevere, Lasting Depression Tied to Heart Patient DeathsDepressed Teens Continue to Suffer into AdulthoodReport Addresses Depression Management in PregnancyDepression's Effect on Pleasure Is RealForeclosures Plunge People Into DepressionSuicide Risk With Antidepressants Falls With AgeCombo Treatment May Ease Depression After StrokeAntidepressant Use in U.S. Has Almost DoubledCan Children Headed for Teen Depression Be Spotted Early?Primary Care Identification of Depression ExaminedGloomy Days Dim Cognitive Powers of the DepressedDepression Poses Pregnancy RisksDepression, Anxiety Bad for the HeartStudy Refutes Depression Gene FindingDrug May Stem Slide Into Alzheimer's for SomeEffects of Depression on Families Need to Be AddressedIf Mom or Dad Is Depressed, Kids Need Help TooEarly Bedtime May Help Stave Off Teen DepressionNew Program May Help Teens at High Risk for Depression
Questions and AnswersBlog EntriesVideosLinksBook ReviewsSelf-Help Groups
Community

Talk about this issue in our mental health support community

Therapist Search
Find a Therapist:
 (USA/CAN only)

Use our Advanced Search to locate a therapist outside of North America.

Related Topics

Anxiety Disorders
Bipolar Disorder
Suicide
Addictions: Alcohol and Substance Abuse
Pain Management
View the Depression Primer - an illustrated book about Depression

Studies Explore Genetic Factors Underlying Depression

(HealthDay News)
by -- Eric Metcalf
Updated: Sep 11th 2009

new article illustration

FRIDAY, Sept. 11 (HealthDay News) -- Multiple genetic factors may help predict patient response to antidepressants, and a haplotype in the CRHR1 gene may help protect individuals who were subjected to childhood mistreatment from depression in adulthood, according to the results of two studies published in the September Archives of General Psychiatry.

In the first study, Guilherme Polanczyk, M.D., of Duke University in Durham, N.C., and colleagues analyzed data from a group of 1,116 women in the E-Risk Study and 1,037 men and women in the Dunedin Study. In the first group, women reported on childhood mistreatment using the Childhood Trauma Questionnaire. Mistreatment was measured using a different method in the second group. In the first group, a TAT haplotype formed by rs7209436, rs110402, and rs242924 in CRHR1 was associated with a protective effect against depression, supporting earlier research, but this finding wasn't seen in the other group.

In the second study, Marcus Ising, Ph.D., of the Max Planck Institute of Psychiatry in Munich, Germany, and colleagues discuss the results of a genome-wide association study in 339 inpatients with a depressive episode and two replication studies in individuals with depression or major depression. Analysis revealed a binary variable that grouped patients into carriers of a high or low number of response alleles in predicting the outcome of antidepressant treatment in two samples.

"The present results demonstrate the importance of multiple genetic factors in the prediction of antidepressant drug response, which underscores the multifactorial nature of this trait. In particular, these findings imply a cumulative effect of genetic variations and clinical features. Both types of variables contributed similar effects with respect to prediction of treatment outcome," Ising and colleagues conclude.

Abstract - Polanczyk
Full Text (subscription or payment may be required)
Abstract - Ising
Full Text

Follow us on Twitter!

Find us on Facebook!





powered by centersite dot net