Resources  email page print page Basic Information Introduction and Types of Depression Major Depression and other Unipolar DepressionsClassic Symptoms of Major DepressionUnderstanding Mood Episodes in DepressionThe Course of Major DepressionDSM Specifiers for Major DepressionPrevalenceFormal DSM Diagnoses for Other Depressive Mood DisordersSymptoms - Dysthymic DisorderFormal DSM Diagnoses Continued Related Disorders / Conditions Other Conditions Related to DepressionMajor Depression Related Conditions ContinuedMajor Depression Related Conditions ConclusionThe Far Reaches of Depression Historical and Current Understandings Historical Understandings of DepressionHistorical Understandings of Depression ContinuedCurrent Understandings of Major Depression - Biopsychosocial ModelCurrent Understandings of Major Depression - Diathesis-Stress Model Biology, Psychology and Sociology Biology of Depression - NeurotransmittersBiology of Depression - Neuroplasticity and EndocrinologyBiology of Depression - Genetics and ImagingBiology of Depression - PsychoneuroimmunologyPsychology of Depression- Psychodynamic TheoriesPsychology of Depression- Behavioral TheoriesCognitive Theories of Major Depression - Aaron BeckCognitive Theories of Major Depression - Ellis and BanduraCognitive Theories of Major Depression - SeligmanSociology of Depression - Effects of CultureSocial and Relational Factors in Major DepressionLifestyle Factors and Environmental Causes of Major Depression Treatment - Medication and Psychotherapy Treatment: When to Seek Professional Help and Where to Find Help for Major DepressionMeasuring DepressionClinician-Rated and Self-Report Questionnaires/Tests for Major DepressionModes of TreatmentMedications for Major DepressionAntidepressants for Major Depression - SSRIsAntidepressants for Major Depression - SSNIsAntidepressants for Major Depression - With Children, TCAs, and MAOIsMood Stabilizers for Major DepressionNon-pharmaceutical Medical Therapies for Major DepressionPsychotherapy - Evidence-Based Treatments for Major DepressionCognitive Behavioral Therapy for Major DepressionCognitive Behavioral Therapy for Major Depression ContinuedInterpersonal Therapy for Major DepressionOther Forms of Psychotherapy for Major Depression - Behavior TherapyOther Forms of Psychotherapy for Major Depression - Psychodynamic TherapyOther Forms of Psychotherapy for Major Depression - Group, Family and Couples Therapy Alternative Medicine and Self-Help Resources Complementary and Alternative Treatments for Major DepressionMajor Depression and St. John's WortMajor Depression and ExerciseMajor Depression and Omega 3 Fatty AcidsMajor Depression Serotonin Precursors: SAMeMajor Depression Serotonin Precursors: 5-HTPLess Well-Studied CAM Remedies For Depression - B-Vitamins and Traditional Chinese MedicineLess Well-Studied CAM Remedies For Depression - Ayurveda and HomeopathySelf-Help Methods for Major Depression Community and On-line Self-Help Resources for Major Depression Depression Reading List Special Issues Further Observations Regarding Major Depression Treatment and Special Issues - SuicideSpecial Issues - Severe Depression, Dual Depression and Dual Diagnosis References Depression Article References More Information Aging and DepressionAntidepressants No Better Than Placebo Says A New Study, But It's Really More Complicated Than That... 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What is Going On With Me?I'm Afraid I'm Going CrazyI Don't Know What To DoAm I Wallowing in Depression?AngerSexual Abuse and Its Effects on Relationships AfterwardsWhat Is Wrong with Me, Doc? HelpDBSAm I Suffering a Kind of Psychological Problem? Blog Entries Depression, ADHD, Psychotherapy and MedicationKeeping You Sane: Do You Need a Day Out? Exploring the Upside of ADHDHow to Gain Control of Your Mind, Instead of Your Mind Controlling YouWhat You Need to Know about H1N1 and DepressionMindfulness and ADHD: A Tip from Dr. Lidia ZylowskaFreedom from Your Anxious MindThe Existential Crisis, Depression, Anxiety and MortalityADHD - Breaking the Cycle of ShameFeeling Good, It's Not Just In the BrainAre You Wired to Worry? Children, ADHD and Stimulant MedicationNational Depression Screening Day, Thursday October 8, 2009Mental Health: Our Troubled TeenagersDepression and Its MeaningsTeenage Depression and Consequences5 Steps to Emotional Freedom: Placebo or Panacea?Couples Therapy for Robert and Julia (Romeo and Juliet)New Research: Mindfulness-Based Program as Effective as Antidepressant MedicationAnxiety as a Defense Against Depression: Part 7Students and College, A Stressful Time of Life: Parents and Students BewareAnxiety as a Defense Against Depression: Part 6Brain Neuroplasticity and Treatment Resistant DepressionWhy People Might Use Anxiety to Avoid Depression: Part 5Feeling Stuck? 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THURSDAY, Oct. 15 (HealthDay News) -- Men who take the antidepressant nortriptyline (Aventyl) are nearly 10 times more likely to have suicidal thoughts than those who use the antidepressant escitalopram (Lexapro, Cipralex), a new study has found.

The study, published online Oct. 15 in BMC Medicine, included 811 people with moderate to severe unipolar depression. Though it found an overall reduction in suicidal thoughts, men who took nortriptyline were found to have a 9.8-fold increase in emerging suicidal thoughts and a 2.4-fold increase in worsening suicidal thoughts, compared with those who took escitalopram.

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"Our findings that treatment-emerging and worsening suicidal thoughts may also be associated with psychomotor activation triggered by antidepressants need to be investigated in future studies," the study team's leader, Dr. Nader Perroud, from the Institute of Psychiatry at King's College London, said in a news release from the journal's publisher.

"The study also refutes the idea that newer antidepressants such as the SSRIs [selective serotonin reuptake inhibitors] are worse than older medications in terms of increasing suicidal thoughts," Perroud added.

Nortriptyline is a tricyclic antidepressant that inhibits the reuptake of noradrenaline and, to a lesser degree, that of serotonin, according to background information in the news release. Escitalopram is an SSRI.

More information

The U.S. Agency for Healthcare Research and Quality has more about antidepressants.

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