Resources  email page print page Basic Information Introduction and Types of Depression Major Depression and other Unipolar DepressionsClassic Symptoms of Major DepressionUnderstanding Mood Episodes in DepressionThe Course of Major DepressionDSM Specifiers for Major DepressionPrevalenceFormal DSM Diagnoses for Other Depressive Mood DisordersSymptoms - Dysthymic DisorderFormal DSM Diagnoses Continued Related Disorders / Conditions Other Conditions Related to DepressionMajor Depression Related Conditions ContinuedMajor Depression Related Conditions ConclusionThe Far Reaches of Depression Historical and Current Understandings Historical Understandings of DepressionHistorical Understandings of Depression ContinuedCurrent Understandings of Major Depression - Biopsychosocial ModelCurrent Understandings of Major Depression - Diathesis-Stress Model Biology, Psychology and Sociology Biology of Depression - NeurotransmittersBiology of Depression - Neuroplasticity and EndocrinologyBiology of Depression - Genetics and ImagingBiology of Depression - PsychoneuroimmunologyPsychology of Depression- Psychodynamic TheoriesPsychology of Depression- Behavioral TheoriesCognitive Theories of Major Depression - Aaron BeckCognitive Theories of Major Depression - Ellis and BanduraCognitive Theories of Major Depression - SeligmanSociology of Depression - Effects of CultureSocial and Relational Factors in Major DepressionLifestyle Factors and Environmental Causes of Major Depression Treatment - Medication and Psychotherapy Treatment: When to Seek Professional Help and Where to Find Help for Major DepressionMeasuring DepressionClinician-Rated and Self-Report Questionnaires/Tests for Major DepressionModes of TreatmentMedications for Major DepressionAntidepressants for Major Depression - SSRIsAntidepressants for Major Depression - SSNIsAntidepressants for Major Depression - With Children, TCAs, and MAOIsMood Stabilizers for Major DepressionNon-pharmaceutical Medical Therapies for Major DepressionPsychotherapy - Evidence-Based Treatments for Major DepressionCognitive Behavioral Therapy for Major DepressionCognitive Behavioral Therapy for Major Depression ContinuedInterpersonal Therapy for Major DepressionOther Forms of Psychotherapy for Major Depression - Behavior TherapyOther Forms of Psychotherapy for Major Depression - Psychodynamic TherapyOther Forms of Psychotherapy for Major Depression - Group, Family and Couples Therapy Alternative Medicine and Self-Help Resources Complementary and Alternative Treatments for Major DepressionMajor Depression and St. John's WortMajor Depression and ExerciseMajor Depression and Omega 3 Fatty AcidsMajor Depression Serotonin Precursors: SAMeMajor Depression Serotonin Precursors: 5-HTPLess Well-Studied CAM Remedies For Depression - B-Vitamins and Traditional Chinese MedicineLess Well-Studied CAM Remedies For Depression - Ayurveda and HomeopathySelf-Help Methods for Major Depression Community and On-line Self-Help Resources for Major Depression Depression Reading List Special Issues Further Observations Regarding Major Depression Treatment and Special Issues - SuicideSpecial Issues - Severe Depression, Dual Depression and Dual Diagnosis References Depression Article References More Information Aging and DepressionAntidepressants No Better Than Placebo Says A New Study, But It's Really More Complicated Than That... Blunt InstrumentsBrain Neuroplasticity and Treatment Resistant DepressionComing Out of the Depression ClosetCosmo Magic to Cyclothymic: Highs, Lows and States of FlowDepression and CancerDepression and DiabetesDepression and Heart DiseaseDepression and HIV/AIDSDepression and ParkinsonsDepression and StrokeDepression and WomenDepression, ADHD, Psychotherapy and MedicationDysthymic Disorder SymptomsElliott Smith and the gift of Vulnerability MusicFeeling Good, It's Not Just In the BrainGoing Postal: The Road to Depression and SalvationGuest Editorial: Celeb Feud Brought Up Critical IssuesHelping Children Understand and Cope with Parental DepressionListening to Readers on Prozac, Depression & the Medical System: Part IListening to Readers on Prozac, Depression & the Medical System: Part IIMajor Depression SymptomsMen and DepressionNational Depression Screening Day, Thursday October 8, 2009Older Adults: Depression and Suicide FactsOrganizationsPost Partum Depression and The Importance of SleepReader Feedback on the Depression SeriesRunning On FiftySt. John's Wort FAQStudents and College, A Stressful Time of Life: Parents and Students BewareSymptoms of Depressive DisordersThe Biochemical - Psychosexual Revolution: Getting Up and Close while Being Down and OutThe Existential Crisis, Depression, Anxiety and MortalityThe Liberating and Entangling Webs of Technology, Depression and ProzacThe Long Term Effects of BullyingTop Twelve Tips for Beating (Mostly) Moderate Chronic Clinical DepressionTreatmentTreatment 1 of 2Treatment 2 of 2Unmasking Mental IllnessWebsitesWhat about the "milder" depression: Dysthymic disorder?Why People Might Use Anxiety to Avoid Depression: Part 2Why People Might Use Anxiety to Avoid Depression: What We Can Learn From a Wartime ExperienceWise Counsel Interview Transcript: An Interview with James Gordon MD on Mind Body Medicine and His Book 'Unstuck'Wise Counsel Interview Transcript: An Interview with with Ronald Dworkin, MD, Ph.D. on Artificial Happiness Tests Goldberg Depression Questionnaire Latest News Phone Care Can Help Combat Post-Heart Surgery DepressionClinical Trials Update: Nov. 16, 2009Depression Linked to Immune Response in PregnancyClinical Trials Update: Nov. 12, 2009Health Tip: Symptoms of Postpartum DepressionBrain Stimulation May Ease Treatment-Resistant DepressionClinical Trials Update: Nov. 9, 2009Adjunctive Psychotherapy for Depression StudiedDepression May Blur Memory of Aches and PainsCognitive Behavioral Therapy Helps Overcome Winter BluesPsychotherapy Beats Light Treatment for SADPhone Counseling for Depression Rings With PromiseDepression Often Goes Untreated in Working MomsConstant Light Linked to Symptoms of DepressionOmega-3 Augmentation of Antidepressant EvaluatedSuicidal Thoughts May Vary by AntidepressantImpact of Maternal Depression and Abuse on Children StudiedRecession Adds to Ranks of Americans With DepressionDepression, Anxiety May Raise Odds of ObesityTelephone Care and Therapy Help to Treat DepressionMother's Use of Antidepressant May Carry Risks for NewbornTroubled Minds Can Mean Wider WaistlinesTeens With ADHD, Depression Risk Internet AddictionAntidepressants May Be Linked to Birth ProblemsMediterranean Diet May Help Prevent DepressionAntidepressants Linked to Heart Defects in NewbornsPredicting Postpartum Depression May Be PossibleDrinking, Weight, Depression Linked in Young Women: StudyHealth Care Assistants May Be Useful in Depression CareDepression May Hasten Cancer DeathStudies Explore Genetic Factors Underlying DepressionSevere, Lasting Depression Tied to Heart Patient DeathsDepressed Teens Continue to Suffer into AdulthoodReport Addresses Depression Management in PregnancyDepression's Effect on Pleasure Is RealForeclosures Plunge People Into DepressionSuicide Risk With Antidepressants Falls With AgeCombo Treatment May Ease Depression After StrokeAntidepressant Use in U.S. Has Almost DoubledCan Children Headed for Teen Depression Be Spotted Early?Primary Care Identification of Depression ExaminedGloomy Days Dim Cognitive Powers of the DepressedDepression Poses Pregnancy RisksDepression, Anxiety Bad for the HeartStudy Refutes Depression Gene FindingDrug May Stem Slide Into Alzheimer's for SomeEffects of Depression on Families Need to Be AddressedIf Mom or Dad Is Depressed, Kids Need Help TooEarly Bedtime May Help Stave Off Teen DepressionNew Program May Help Teens at High Risk for Depression Questions and Answers Help Me Please. What is Going On With Me?I'm Afraid I'm Going CrazyI Don't Know What To DoAm I Wallowing in Depression?AngerSexual Abuse and Its Effects on Relationships AfterwardsWhat Is Wrong with Me, Doc? HelpDBSAm I Suffering a Kind of Psychological Problem? Blog Entries Depression, ADHD, Psychotherapy and MedicationKeeping You Sane: Do You Need a Day Out? Exploring the Upside of ADHDHow to Gain Control of Your Mind, Instead of Your Mind Controlling YouWhat You Need to Know about H1N1 and DepressionMindfulness and ADHD: A Tip from Dr. Lidia ZylowskaFreedom from Your Anxious MindThe Existential Crisis, Depression, Anxiety and MortalityADHD - Breaking the Cycle of ShameFeeling Good, It's Not Just In the BrainAre You Wired to Worry? Children, ADHD and Stimulant MedicationNational Depression Screening Day, Thursday October 8, 2009Mental Health: Our Troubled TeenagersDepression and Its MeaningsTeenage Depression and Consequences5 Steps to Emotional Freedom: Placebo or Panacea?Couples Therapy for Robert and Julia (Romeo and Juliet)New Research: Mindfulness-Based Program as Effective as Antidepressant MedicationAnxiety as a Defense Against Depression: Part 7Students and College, A Stressful Time of Life: Parents and Students BewareAnxiety as a Defense Against Depression: Part 6Brain Neuroplasticity and Treatment Resistant DepressionWhy People Might Use Anxiety to Avoid Depression: Part 5Feeling Stuck? Two Things You Need to Know to Make a Change Why People Might Use Anxiety to Avoid Depression: Part 4Childhood, Parental Loss and DepressionOne Strategy You Need to Know for Bipolar DisorderWhy People Might Use Anxiety to Avoid Depression: Part 3Psychiatric Meds: The Personal Debate Over UseWhy People Might Use Anxiety to Avoid Depression: Part 2Are You at Risk for Depression? Here's One Way to Find OutWhat about the "milder" depression: Dysthymic disorder?Why People Might Use Anxiety to Avoid Depression: What We Can Learn From a Wartime ExperienceBipolar Mood Swings? 4 Steps to Nip Them in the BudElisha Goldstein's Top 10 Mental Help Blog Posts3 Steps Out of Helplessness Post Partum Depression and The Importance of Sleep"The Big Emptiness": Hoarding, OCD, Depression and the Quest for MeaningFeeling Depressed? 3 Steps to HappinessDoes Psychotherapy Help Everyone?Of Parking Lots, Stress, Life and PsychotherapyFeeling Stuck with Anxiety or Depression? Try this Today! 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TUESDAY, Oct. 20 (HealthDay News) -- Giving omega-3 fatty acids along with sertraline to patients with depression and coronary heart disease (CHD) did not augment the effect of the antidepressant, according to a study in the Oct. 21 issue of the Journal of the American Medical Association.

Robert M. Carney, Ph.D., of the Washington University School of Medicine in St Louis, and colleagues randomized 122 patients with major depression and CHD to a regimen of 50 mg/d of the selective serotonin reuptake inhibitor sertraline and either 2 g/d of omega-3 acid ethyl esters (930 mg of eicosapentaenoic acid [EPA] and 759 mg of docosahexaenoic acid [DHA]) or placebo for a period of 10 weeks. The main outcome measures were scores on the Hamilton Rating Scale for Depression (HAM-D) or the Beck Depression Inventory (BDI-II).

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The researchers reported no significant differences between the groups taking omega-3 or placebo in weekly BDI-II or HAM-D scores, in 10-week mean BDI-II or mean HAM-D scores, nor in any of the indicators of depression remission or response.

"Treatment of patients with CHD and major depression with sertraline and omega-3 fatty acids did not result in superior depression outcomes at 10 weeks, compared with sertraline and placebo. Whether higher doses of omega-3 or sertraline, a different ratio of EPA to DHA, longer treatment, or omega-3 monotherapy can improve depression in patients with CHD remains to be determined," the authors write.

GlaxoSmithKline supplied the omega-3 and placebo capsules and Pfizer supplied the sertraline. Two of the study authors reported receiving honoraria, speaker fees, or advisory fees from, or having stock in, pharmaceutical companies.

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