- Heroin and the brain
- Post Traumatic Stress Disorder (PTSD)
- Anxiety Disorder and Heroin Abuse
- Mental health consequences of HIV
Tolerance to the effects of heroin occurs very quickly, such that a higher dose is required to achieve the same high. Due to the nature of this escalation, there is an increase in the risk of overdose and death. Heroin interacts with the 'pain perception' mechanisms of the human body. Heroin is an illicit opioid drug that is converted into morphine once it enters the brain, then binds to opioid receptors in the brain, brain stem, and the body. Morphine imitates the actions of endogenous opioids, which are produced naturally in the body, and causes analgesia (pain relief). If GABA levels are reduced, then dopamine is released and the user feels euphoria and pleasure. Dopamine is a neurotransmitter commonly associated with the reward pathway in the brain and is responsible for the reinforcing properties of heroin use and subsequent addiction. Long-term heroin use has profound negative effects on the brain and behavior.
What is Heroin?Heroin is a synthetic opioid derived from the naturally occurring opioid morphine.
Heroin and the brain
This opioid inhibits gamma-aminobutyric acid (GABA), a neurotransmitter that decreases dopamine presence in the brain.
Tolerance to the effects of heroin occurs very quickly, such that a higher dose is required to achieve the same high. Due to the nature of this escalation, there is an increase in the risk of overdose and death.
Heroin interacts with the 'pain perception' mechanisms of the human body. Heroin is an illicit opioid drug that is converted into morphine once it enters the brain, then binds to opioid receptors in the brain, brain stem, and the body.
Morphine imitates the actions of endogenous opioids, which are produced naturally in the body, and causes analgesia (pain relief).
If GABA levels are reduced, then dopamine is released and the user feels euphoria and pleasure.
Dopamine is a neurotransmitter commonly associated with the reward pathway in the brain and is responsible for the reinforcing properties of heroin use and subsequent addiction.
Long-term heroin use has profound negative effects on the brain and behavior.
An important point to note about the pain perception mechanisms of heroin is that it does not distinguish between physical and emotional pain.
- Meaning that a person will experience emotional pain in the same way.
- MRI studies examining this issue have revealed that pain-related centers of the brain show increased activity when a person is experiencing negative emotional arousal.
Heroin is a highly addictive and life-threatening opioid drug that decreases pain, induces euphoria and warmth, and causes drowsiness.
- According to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), those who are addicted to opioids have an increased risk of developing persistent depressive disorder and in some instances, major depressive disorder.
- It is estimated that nearly half of all opioid addicts have experienced depression at some point in their lives.
- Furthermore, those suffering from a heroin addiction are 14 times more likely to commit suicide than their non-addicted peers.
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Post Traumatic Stress Disorder (PTSD)
PTSD may also be comorbid with heroin abuse. While one may not be causative of the other, their association may be due to a number of shared factors (including those of a psychological, genetic or environmental nature) that may increase the susceptibility to both conditions.
Psychological factors again arise in pain and avoidance.
You Can Recover With integrated therapy, both the heroin abuse or addiction and mental health condition can be treated. Don't delay your recovery.
- In anxiety and PTSD, experiential avoidance and anxiety sensitivity has been linked to severity of symptomology.
- The ability to increase pleasure pathways through heroin abuse allows for avoidance of pain triggers creating an incentive to use heroin and therefore, providing an explanation of how substance abuse disorders can arise in individuals with PTSD.
- Research seems to support the link between PTSD and heroin abuse—in some cases, the severity of heroin abuse is directly proportional to the severity of PTSD symptoms.
While no pharmacological treatment has been established specifically for the treatment of PTSD, there is some indication that a lack of adherence to heroin maintenance treatments, like methadone, are correlated with an increase in severity of PTSD symptoms.
- This correlation suggests that PTSD and heroin abuse are inextricably linked and improvement in the heroin addiction domain will inevitably have effects on the reduction of PTSD.
Anxiety Disorder and Heroin Abuse
The relationship between anxiety disorders and opiate dependence is complicated because:
- Anxiety and/or anxiety disorders may be a consequence of the addiction due to the effects of using, abstinence (withdrawal development) and effects of the using environment.
- However, the high comorbidity suggests that underlying anxiety may result in the actual dependence, i.e., anxiety came first and the self-medication hypothesis applies.
Because of the complex nature of this comorbidity, some recommendations have been made to accurately diagnose and manage both opiate dependence and anxiety disorders. These include:
- Patients presenting with opiate dependence should be screened for anxiety problems and vice versa, because early identification has important treatment implications.
- Integrated treatment has been emphatically recommended, such that treating a comorbid anxiety disorder must complement the pharmacological interventions for treating opiate dependence.
- Evidence-based recommendations for treating anxiety disorders involve a combination of antidepressant therapy and cognitive-behavioral treatment.
- The use of benzodiazepines should be avoided in this population due to the increased risk of developing abuse or dependence, as comorbid benzodiazepine abuse in opiate dependent patients seems to be significant.
Mental health consequences of HIV
Heroin abuse by intravenous administration may lead to blood-borne disease such as the human immunodeficiency virus (HRV). This is due to the risks involved in sharing needles and/or irresponsible needle use habits that impair the sterility of syringes. In a four-year study of patients at a treatment facility for addiction, 61% had contracted HIV.
Other factors that contribute to this correlation are:
- Mental illness: This is due to the link between poor impulse control and risk taking behaviors.
- History of abuse (physical, sexual and emotional): This is due to this population being more likely to abuse substances and practice risk-taking behaviors.
1-888-993-3112Who Answers? to learn about inpatient recovery programs. Be sure to ask whether they are qualified to treat dually-diagnosed heroin and mental health conditions. You can also use the Substance Abuse and Mental Health Services Administration (SAMHSA) treatment finding tool to look for inpatient and outpatient programs near you.
Call 1-888-993-3112Who Answers? to learn about inpatient recovery programs. Be sure to ask whether they are qualified to treat dually-diagnosed heroin and mental health conditions.
You can also use the Substance Abuse and Mental Health Services Administration (SAMHSA) treatment finding tool to look for inpatient and outpatient programs near you.
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